Administration

Parameters

Governing Equations

Two-Compartment Model (IV Bolus)

C1(t) = A·e^(-α·t) + B·e^(-β·t)

Where:
  α + β = k10 + k12 + k21
  α·β = k10·k21
  k10 = CL / Vc
  k12 = Q / Vc
  k21 = Q / Vp
  A = Dose/Vc · (k21 - α)/(β - α)
  B = Dose/Vc · (k21 - β)/(α - β)

AUC(0-∞) = Dose / CL
Cmax = A + B (IV bolus)
t½β = ln(2) / β