End-to-end pharmaceutical simulations: PK/PD, clinical trials, formulation, bioprocessing, regulatory, and health economics. The most in-demand sim suite in life sciences.
IV bolus, infusion, and oral absorption with first-order elimination. Real-time plasma concentration-time curves, Cmax, Tmax, AUCinf, clearance, and volume of distribution.
Sigmoidal Emax model with Hill coefficient, EC50, and IC50. Watch receptor occupancy shift as you titrate agonist, antagonist, or allosteric modulator concentrations.
Lipinski's Rule of Five, logP, solubility, permeability, and BCS classification. First-pass hepatic extraction and bioavailability fraction update in real-time as you modify the molecule.
2×2 crossover design with TOST procedure. Real-time 90% CI calculation for Cmax and AUC, intra-subject CV, and sample size power curve as you adjust bioavailability delta.
USP I basket and USP II paddle apparatus. Adjust paddle speed, media pH, and ionic strength. Real-time f2 similarity factor calculation for biowaiver justification.
Heckel and Kawakita analysis of compression force vs. porosity. Real-time hardness, friability, and disintegration time prediction as you adjust punch pressure and dwell time.
Temperature and humidity stress with Arrhenius degradation kinetics. Predict shelf life (t90), activation energy, and expiry date from accelerated data in real-time.
Column chemistry selection, mobile phase gradient, and flow rate optimization. Real-time resolution (Rs), tailing factor (Tf), theoretical plates (N), and pressure drop.
Media fill run with contamination probability modeling. Grade A/B airflow visualization, operator intervention risk, and particle monitoring with alert/action limits.
Primary and secondary drying with collapse temperature (Tc) monitoring. Sublimation rate, chamber pressure, and cake resistance update as you ramp shelf temperature.
CHO or HEK293 cell culture with glucose feed, lactate shift, and viable cell density tracking. Real-time titer, specific productivity (Qp), and perfusion rate optimization.
Protein A capture, ion exchange, and hydrophobic interaction chromatography. Real-time yield, purity, HCP and DNA clearance, and column lifetime tracking.
Salt screening, co-solvent, surfactant, and amorphous solid dispersion strategies. Real-time supersaturation index, thermodynamic vs kinetic solubility, and precipitation risk.
MTD, NOAEL, and safety margin determination with allometric scaling. TK evaluation, dose-proportionality assessment, and toxicokinetic safety window visualization.
Patient recruitment curve with dropout modeling, interim analysis triggers, and adaptive design gates. Real-time power curve and sample size re-estimation.
NONMEM-style nonlinear mixed-effects modeling. Covariate effects on CL and V, ETA distribution, VPC, and bootstrap confidence intervals in real-time.
Tier 1 critical quality attributes with equivalence margin testing. Analytical similarity index, immunogenicity risk scoring, and fingerprint comparison.
Full factorial, fractional factorial, and response surface methodology. Design space boundary, normal operating range (NOR), and proven acceptable range visualization.
NIR spectroscopy with multivariate PLS models. Real-time assay, content uniformity, and moisture prediction with control chart limits for RTRT.
Module 1–5 structure assembly with lifecycle management. Real-time validation against ICH eCTD 4.0 spec, hyperlink checking, and PDF technical compliance.
Disproportionality analysis with PRR, ROR, and IC calculation. Temporal pattern scanning, case triage priority scoring, and regulatory threshold alerts.
Temperature excursion mapping across distribution lanes. Thermal packaging qualification, stability budget burn rate, and GDP compliance deviation tracking.
Markov state-transition model with Monte Carlo microsimulation. QALY accumulation, incremental cost-effectiveness ratio (ICER), budget impact, and tornado sensitivity.
DAR distribution modeling, payload release kinetics, and bystander effect radius. Therapeutic index window and off-target toxicity probability in real-time.
In vitro transcription, enzymatic capping, and LNP microfluidic encapsulation. Real-time encapsulation efficiency, particle size (DLS), integrity, and potency tracking.
From £9.99/month for professionals. Unlimited access to all 25 pharmaceutical simulations with GxP-aligned data export, batch records, and early access to new releases.
See Pricing Plans →